Hawaii Macula and Retina Institute Publications

HRMI prioritizes sharing research and ideas that have been developed at our center.  PDFs that are available can be accessed by clicking on the article name.  Reprint requests should be sent to: research@retinahi.com

C. Hoeppner, N.F. Callaway, N.Z. Gregori, A. Yuan, A. Rachitskaya, H. Ameri, J.F. Arevalo, A.J. Augustin, D. Birch, G. Dagnelie, J.L. Davis, S. Grisanti, J. Handa, A. Ho, S. Huang, M. Humayun, R. Iezzi, T. Jayasundera, G.T. Kokame, B.L. Lam, J.I. Lim, N. Mandava, S. Montezuma, L.C. Olmos de Koo, S. Rizzo, P. Szurman, L. Vajzovic, J. Weiland, P.M. Wiedemann, J. Yan, D.N. Zacks (the Argus II OCT Study Group within Post-market Approval Study). Optical Coherence Tomography Characteristics Among Subjects Implanted with the Argus II Retinal Prosthesis System. Paper, ARVO 2017, Baltimore, MD, May 10, 2017.

Kokame GT. Management of subretinal hemorrhage. Yan Ke Xue Bao 2017. doi: 10.3978/j.issn.1000-4432.2017.01.01

Kokame GT, Tom ES, Shantha JG. Update on advances in polypoidal choroidal vasculopathy – a subtype of subretinal neovascularization. Macular Degeneration 2016 Sep; 1: 2-32.

Kokame GT, Shantha JG, Hirai K, Ayabe J. En-face spectral domain optical coherence tomography for the diagnosis and evaluation of polypoidal choroidal vasculopathy. Ophthalmic Surg Lasers Imaging Retina 2016 Aug;47(8):737-44.

Kokame GT, Lai JC, Wee R, Yanagihara R, Shantha JG, Ayabe J, Hirai K. Prospective clinical trial of intravitreal aflibercept treatment for polyploidal choroidal vasculopathy with hemorrhage or exudation (EPIC study): 6 month results. BMC Ophthalmology 2016 Feb; 16(127):1-10.

Stoller G, Kokame GT, Dreyer RF, Shapiro H, Tuomi L.  Patterns of early and delayed visual response to ranibizumab treatment for neovascular are-related macular degeneration.  JAMA Ophthalmol 2016: 134(5): 545-553.

Kokame GT, Yanagihara R, Hirai K. Polypoidal Choroidal Vasculopathy – Imaging by Indocyanine Green Angiography and En Face Optical Coherence Tomography. JAMA Ophthalmology 2015: in press.

Pereira FB, Veloso CE, Nehemy MB, Kokame GT. Characterization of neovascular macular degeneration in Brazilian patients. Ophthalmologica 2015; in press.

Kokame GT.  Prospective evaluation of subretinal vessel location in polypoidal choroidal vasculopathy (PCV) and response of hemorrhagic and exudative PCV to high dose antiangiogenic therapy. Trans Am Ophthalmol Soc  2014 in press.

Kokame GT. Prospective evaluation of subretinal location  in polypoidal choroidal vasculopathy (PCV) and response of exudative and hemorrhagic PCV to high dose anti-angiogenic therapy (An  American Ophthalmological Society Thesis).  Trans Am Ophthalmol Soc 2014; 112: 74 – 93.

Chhablani J, Kokame GT.  Diagnostic and therapeutic challenges.  Retina 2014; 34(7): 1485 – 1486

Lim JI, Glassman AR, Aiello LP, Chakravarthy U, Flaxel CJ, Spaide RF, Macula Society CSC Collaborative Study Group (Kokame GT – investigator).  Collaborative retrospective study of photodynamic therapy for chronic central serous chorioretinopathy.  Ophthalmology 2014;  121(5): 1073 – 1078.

Kokame GT.  Posteriorly dislocated intraocular lenses.  In. Han DP.  Cataract Surgery and Retinal Disease.  Optimizing Visual Outcome1e.  November 2013.  Bryn Mawr, Wayne, PA, pp.  55 – 60.

Kokame GT, Han DP.  Combining Cataract Surgery and Posterior Vitrectomy. In Han DP.  Cataract Surgery and Retinal Disease.  Optimizing Visual Outcome. November 2013. Bryn Mawr, Wayne, PA, pp. 55 – 60.

Sarraf D, Kokame GT. Laser video ICG angiography and SD-OCT for the diagnosis of PCV and AMD. Retina Today. Sept 2013.

Capone A Jr, Singer MA, Dodwell DG, Dreyer RF, Oh KT, Roth DB, Walt JG, Scott LC, Hollander DA. Efficacy and Safety of Two or More Dexamethasone Intravitreal Implant Injections For Treatment of Macular Edema Related to Retinal Vein Occlusion (SHASTA Study). Retina. 2013 Jul; Epub ahead of print. PubMed PMID: 23846381.

Kokame GT, Yeung L, Teramoto K, Lai JC, Wee R.  Polypoidal choroidal vasculopathy exudation and hemorrhage – results of ranibizumab therapy at one year.  Ophthalmologica 2013; In press.

Kokame GT. Polypoidal Choroidal Vasculopathy — an Important Diagnositic Tool with Therapeutic Implications.  Retina. 2012 Sep;32(8):1446-8.  PubMed PMID: 22922845.

Aiello LP, Vignati L, Sheetz MJ, Zhi X, Girach A, Davis MD, Wolka AM, Shahri N, Milton RC; PKC-DRS and PKC-DRS2 Study Groups. Oral protein kinase c β inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss amount 813 patients (1,392 eye) with diabetic retinopathy in the Protein Kinase C β Inhibitor-Diabetic Retinopathy Study and the Protein kinase C β Inhibitor-Diabetic Retinopathy Study 2.  Retina. 2011 Nov;31(10):2084-94.  PubMed PMID: 21862954.

Yeung L, Kokame GT, Brod RD, Lightman DA, Lai JC. Pneumatic retinopexy for retinal detachment associated with severe choroidal detachment. Retina. 2011 Jan;31(1):87-92. PubMed PMID: 20714274.

Bui AT, Rosen BS, Roe RH, Kokame GT. Diagnostic and therapeutic challenges. Retina. 2010 Nov-Dec;30(10):1744-8.  PubMed PMID: 20683382.

Diabetic Retinopathy Clinical Research Network Writing Committee, Haller JA, Qin H, Apte RS, Beck RR, Bressler NM, Browning DJ, Danis RP, Glassman AR, Googe JM, Kollman C, Lauer AK, Peters MA, Stockman ME. Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction. Ophthalmology. 2010 Jun;117(6):1087-1093.e3.  Epub 2010 Mar 17. PubMed PMID: 20299105; PubMed Central PMCID: PMC2911350.

Wong RW, Kokame GT, Mahmoud TH, Mieler WF, Tornambe PE, McDonald HR. Complications associated with clear corneal cataract wounds during vitrectomy. Retina. 2010 Jun;30(6):850-5. doi: 10.1097/IAE.0b013e3181c70111. PubMed PMID: 20090563.

Chan CK, Abraham P, Meyer CH, Kokame GT, Kaiser PK, Rauser ME, Gross JG, Nuthi AS, Lin SG, Daher NS. Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections. Retina. 2010 Feb;30(2):203-11. doi: 10.1097/IAE.0b013e3181babda5. PubMed PMID: 19952998.

Kokame GT, Yeung L, Lai JC. Continuous anti-VEGF treatment with ranibizumab for polypoidal choroidal vasculopathy: 6-month results. Br J Ophthalmol. 2010 Mar;94(3):297-301. doi: 10.1136/bjo.2008.150029. Epub 2009 Sep 1. PubMed PMID: 19726427.

Suñer IJ, Kokame GT, Yu E, Ward J, Dolan C, Bressler NM. Responsiveness of NEI VFQ-25 to changes in visual acuity in neovascular AMD: validation studies from two phase 3 clinical trials. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3629-35. doi: 10.1167/iovs.08-3225. Epub 2009 Feb 28. PubMed PMID: 19255158.

Dinç UA, Yenerel NM, Görgün E, Yetik H, Kokame GT, Lim JI. Diagnostic and therapeutic challenges. Retina. 2009 Feb;29(2):275-9. doi: 10.1097/IAE.0b013e3181893787. PubMed PMID: 18827730.

Browning DJ, Glassman AR, Aiello LP, Bressler NM, Bressler SB, Danis RP, Davis MD, Ferris FL, Huang SS, Kaiser PK, Kollman C, Sadda S, Scott IU, Qin H; Diabetic Retinopathy Clinical Research Network. Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema. Ophthalmology. 2008 Aug;115(8):1366-71, 1371.e1. doi: 10.1016/j.ophtha.2007.12.004. PubMed PMID: 18675696; PubMed Central PMCID: PMC2748270.

Diabetic Retinopathy Clinical Research Network. A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema. Ophthalmology. 2008 Sep;115(9):1447-9, 1449.e1-10. doi: 10.1016/j.ophtha.2008.06.015. Epub 2008 Jul 26. PubMed PMID: 18662829; PubMed Central PMCID: PMC2748264.

Chan CK, Meyer CH, Gross JG, Abraham P, Nuthi AS, Kokame GT, Lin SG, Rauser ME, Kaiser PK. Retinal pigment epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration. Retina. 2007 Jun;27(5):541-51. PubMed PMID: 17558314.

Kokame GT, Tokuhara KG. Surgical management of inner lamellar macular hole. Ophthalmic Surg Lasers Imaging. 2007 Jan-Feb;38(1):61-3. PubMed PMID: 17278539.

Kokame GT. Newly recognized serous macular detachment in retinal vascular disease. Retina. 2006 May-Jun;26(5):493-4. PubMed PMID: 16770254.

Kokame GT, Yamaoka S. Subretinal surgery for peripapillary subretinal neovascular membranes. Retina. 2005 Jul-Aug;25(5):564-9. Erratum in: Retina. 2005 Dec;25(8):1123. Yamamoka, Seijo [corrected to Yamaoka, Seijo]. PubMed PMID: 16077351.

Kokame GT, Yamamoto I, Mandel H. Scleral fixation of dislocated posterior chamber intraocular lenses: Temporary haptic externalization through a clear corneal incision. J Cataract Refract Surg. 2004 May;30(5):1049-56. PubMed PMID: 15130643.

Kokame GT, Yamamoto I, Kishi S, Tamura A, Drouilhet JH. Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage. Ophthalmology. 2004 May;111(5):926-30. PubMed PMID: 15121370.

Javellana JA, Drouilhet JH, Kokame GT, Chee PH, Wong BM. Retinal capillary angioma in familial exudative vitreoretinopathy treated with photodynamic therapy. Am J Ophthalmol. 2004 Apr;137(4):780-2. PubMed PMID: 15059735.

Gross JG, Kokame GT, Weinberg DV; Dislocated In-The-Bag Intraocular Lens Study Group. In-the-bag intraocular lens dislocation. Am J Ophthalmol. 2004 Apr;137(4):630-5. PubMed PMID: 15059700.

Kokame GT, Yamamoto I. Silicone oil versus gas tamponade. Ophthalmology. 2004 Apr;111(4):851-2; author reply 852. PubMed PMID: 15051230.

Kokame GT, Germar GG. Successful management of intruded hydrogel buckle with buckle removal, scleral patch graft, and vitrectomy. Retina. 2003 Aug;23(4):536-8. PubMed PMID: 12972767.

Freund KB, Ciardella AP, Yannuzzi LA, Pece A, Goldbaum M, Kokame GT, Orlock D. Peripapillary detachment in pathologic myopia. Arch Ophthalmol. 2003 Feb;121(2):197-204. PubMed PMID: 12583785.

Kokame GT, McCauley MB. Spontaneous reopening of a spontaneously closed macular hole. Am J Ophthalmol. 2002 Feb;133(2):280-2. PubMed PMID: 11812442.

Kokame GT. Management options for early stages of acutely symptomatic macular holes. Am J Ophthalmol. 2002 Feb;133(2):276-8. PubMed PMID: 11812440.

Kokame GT, de Leon MD, Tanji T. Serous retinal detachment and cystoid macular edema in hypotony maculopathy. Am J Ophthalmol. 2001 Mar;131(3):384-6. PubMed PMID: 11239878.

Kokame GT, Atebara NH, Bennett MD. Modified technique of haptic externalization for scleral fixation of dislocated posterior chamber lens implants. Am J Ophthalmol. 2001 Jan;131(1):129-31. PubMed PMID: 11162990.

Kokame GT. Visual field defects after vitrectomy with fluid-air exchange. Br J Ophthalmol. 2001 Jan;85(1):121. PubMed PMID: 11133726; PubMed Central PMCID: PMC1723707.

Kokame GT. Visual field defects after vitrectomy with fluid-air exchange. Am J Ophthalmol. 2000 Nov;130(5):653-4. Review. PubMed PMID: 11078844.

Kokame GT. Vitreous hemorrhage after intravitreal tissue plasminogen activator (t-PA) and pneumatic displacement of submacular hemorrhage. Am J Ophthalmol. 2000 Apr;129(4):546-7. PubMed PMID: 10764874.

Lim JI, Kokame GT, Douglas JP. Multiple evanescent white dot syndrome in older patients. Am J Ophthalmol. 1999 Jun;127(6):725-8. PubMed PMID: 10372888.

Kokame GT. Loss of reading and central vision due to macular diseases–therapeutic management, advances and limitations. Hawaii Med J. 1997 Sep;56(9):245-7. Review. PubMed PMID: 9339054.

Kokame GT. Ultrastructural features of tissue removed during idiopathic macular hole surgery. Am J Ophthalmol. 1997 Mar;123(3):425-6. PubMed PMID: 9063266.

Cohen SM, Kokame GT, Gass JD. Paraproteinemias associated with serous detachments of the retinal pigment epithelium and neurosensory retina. Retina. 1996;16(6):467-73. PubMed PMID: 9002128.

Kokame GT. Macular hole surgery for chronic macular holes. Retina. 1996;16(1):75-8. PubMed PMID: 8927817.

Kokame GT. Reappraisal of biomicroscopic classification of stages of development of a macular hole. Am J Ophthalmol. 1995 Dec;120(6):808-9. PubMed PMID: 8540562.

Kokame GT. Intrapapillary, peripapillary, and vitreous hemorrhage. Ophthalmology. 1995 Jul;102(7):1003-4. PubMed PMID: 9121741.

Kokame GT, de Bustros S. Visual acuity as a prognostic indicator in stage I macular holes. The Vitrectomy for Prevention of Macular Hole Study Group. Am J Ophthalmol. 1995 Jul;120(1):112-4. PubMed PMID: 7611316.

Kokame GT. Clinical correlation of ultrasonographic findings in macular holes. Am J Ophthalmol. 1995 Apr;119(4):441-51. PubMed PMID: 7709968.

Kokame GT. Ultrasound of macular holes. Ophthalmology. 1995 Mar;102(3):366-7. PubMed PMID: 7891970.

Kokame GT. Recurrence of macular holes. Ophthalmology. 1995 Feb;102(2):172-3. PubMed PMID: 7862400.

Kokame GT. Early stage of macular hole in a severely myopic eye. Am J Ophthalmol. 1995 Feb;119(2):240-2. PubMed PMID: 7832238.

Kokame GT, Ing MR. Intraocular gas and low-altitude air flight. Retina. 1994;14(4):356-8. PubMed PMID: 7817030.

Blankenship GW, Flynn HW Jr, Kokame GT. Posterior chamber intraocular lens insertion during pars plana lensectomy and vitrectomy for complications of proliferative diabetic retinopathy. Am J Ophthalmol. 1989 Jul 15;108(1):1-5. PubMed PMID: 2750829.

Lewis ML, Culbertson WW, Post JD, Miller D, Kokame GT, Dix RD. Herpes simplex virus type 1. A cause of the acute retinal necrosis syndrome. Ophthalmology. 1989 Jun;96(6):875-8. PubMed PMID: 2544841.

Kokame GT, Flynn HW Jr, Blankenship GW. Posterior chamber intraocular lens implantation during diabetic pars plana vitrectomy. Ophthalmology. 1989 May;96(5):603-10. PubMed PMID: 2748116.